SNEHA KEREN SANTHOSH
Nijmegen,NL
Summary
Detail-oriented and proactive master's graduate with extensive hands-on research experience in tumor immunology, medicinal chemistry, and biotechnology. Proficient in advanced laboratory techniques such as flow cytometry, qRT-PCR, ELISA, cell culture, and immune-oncology assays. Proven ability to innovate experimental approaches and analyze complex data to drive scientific discoveries. Passionate about drug discovery and therapeutic solutions, especially in immuno-oncology and diabetes.
Overview
4
4
years of professional experience
2
2
years of post-secondary education
Work History
Research Lab Intern
Tumor Immunology Lab, Radboud University
Nijmegen
01.2024 - 09.2024
- Investigated strategies to optimize T-cell activation using PIC Immuno-Brushes and soluble Immuno-Filaments, contributing to enhanced immunotherapeutic approaches for cancer treatment.
- Performed primary cell cultures and T-cell isolation for over 17 experiments, ensuring reliable and reproducible results in cell-based assays.
- Conducted T-cell proliferation assays, long-term cultures, and cytokine quantification using ELISA, supporting immuno-oncology projects.
- Executed flow cytometry analysis and phenotype profiling on T-cell activation states, identifying key surface markers and activation profiles, aligning with immune system modulation.
Research Lab Intern
Institute of Molecules and Materials, Radboud Uni
Nijmegen
02.2023 - 08.2023
- Researched antibacterial resistance mechanisms using bacterial riboswitches to identify novel therapeutic targets for drug development.
- Performed photo-affinity labeling and click chemistry experiments to study interactions between small molecules and RNA, enhancing molecular understanding.
- Conducted Urea PAGE gel analysis and SHAPE experiments to map RNA structure and evaluate binding efficiency under varied experimental conditions.
- Executed in vitro transcription and qRT-PCR experiments, generating accurate data on gene expression.
Junior Scientist Intern
Techkatech Innovation Hub
03.2021 - 06.2021
- Performed a comprehensive literature review on latest technological developments in Human Biology.
- Curated reports on specific topics related to the human body and presented findings weekly, demonstrating effective communication skills.
Education
Master of Science - Medical Biology (Human Biology specialization)
Radboud University
Nijmegen 09.2022 - 09.2024
Bachelor of Science - Biotechnology, Chemistry & Zoology (Triple Major)
St. Joseph's University
Bangalore, India07-2022
Skills
- Flow Cytometry
- Cell Culture
- ELISA
- QRT-PCR
- Assay development
- Immune Cell Isolation
- In Vitro Transcription
- Data analysis (Graph pad and Flowjo)
- Basic skills in R
- Research presentation
- Team collaboration
- Organizational skills
Projects
Research Proposal: The Role of Cancer-Associated Fibroblasts in Pancreatic Ductal Adenocarcinoma (PDAC)
Sept 2023 | Radboud University
- Developed a proposal to explore the crosstalk between cancer-associated fibroblasts (CAFs) and T-cells in PDAC, emphasizing novel immunotherapies and personalized medicine.
- Focused on the immune landscape and therapeutic modulation of CAFs, directly aligning with the focus on innovative biopharmaceutical solutions.
Research Proposal: SOX17 Gene Expression in Zebrafish
May 2022 | St. Joseph's University
- Investigated the role of SOX17 gene expression in the differentiation of pancreatic beta cells in zebrafish, aimed at understanding its impact on insulin-producing cells and diabetes therapy.
Study on Streptococcus Mutans Growth Patterns
Jan 2022 | St. Joseph's University
- Conducted a microbial growth study on Streptococcus mutans, identifying correlations between tooth morphology and dental caries.
Leadership
Cultural Secretary | Green Gene Guild, Biotechnology Association
2019 – 2022 | St. Joseph's University, Bangalore, India
- Led organizational efforts for events and activities, overseeing a team of 10 members, coordinating workshops and organizing fests.
- Developed strong team collaboration, leadership, and organizational skills while managing multitasking and delivering events on time.
Accomplishments
Awarded the Radboud University Scholarship (2022-2024) for academic excellence
Certification
- IELTS score 8.0
- Certification in Introduction to the Biology of Cancer, Coursera.
- Certification in Introduction to Psychology, Coursera.
Timeline
Research Lab Intern
Tumor Immunology Lab, Radboud University
01.2024 - 09.2024
Research Lab Intern
Institute of Molecules and Materials, Radboud Uni
02.2023 - 08.2023
Master of Science - Medical Biology (Human Biology specialization)
Radboud University
09.2022 - 09.2024
Junior Scientist Intern
Techkatech Innovation Hub
03.2021 - 06.2021
- IELTS score 8.0
- Certification in Introduction to the Biology of Cancer, Coursera.
- Certification in Introduction to Psychology, Coursera.
Bachelor of Science - Biotechnology, Chemistry & Zoology (Triple Major)
St. Joseph's University
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