Ronald Boellaard
Wilnis
Overview
30
30
years of professional experience
Work History
Full professor
Amsterdam University Medical Centers
01.2017 - Current
- Full professor (1.0 fte) at the Department of Radiology and Nuclear Medicine of the Amsterdam University Medical Centers, location VU Medical Center.
Full professor
University Medical Centre Groningen
01.2015 - 01.2017
- Full professor (0.2 fte) at the Department of Nuclear Medicine and Molecular Imaging of the University Medical Centre Groningen.
Head of the Imaging Methodology section
VUmc
01.2012 - 01.2015
- Head of the Imaging Methodology section of the department of Radiology & Nuclear Medicine, VUmc, Amsterdam.
Full professor
VUmc
01.2011 - 01.2015
- Appointed as full professor since 1-10-2011.
Coordinator of the PET physics group
VUmc
01.2004 - 01.2012
- Coordinator of the PET physics group (including supervision of all research projects regarding instrumentation, reconstruction, data analysis, quantification and kinetic modelling), permanent term.
Clinical Physicist
VUmc
01.2001 - 01.2004
- Clinical Physicist, Department of Nuclear Medicine and PET Research, VUmc, Amsterdam, 1.0 fte.
Training for clinical physicist
VUmc
01.1998 - 01.2001
- Training for clinical physicist
- Department of Nuclear Medicine and PET Research, VUmc, Amsterdam, 1.0 fte, tenured term
- Certificate obtained in 2001.
PhD student
Netherlands Cancer Institute
01.1994 - 01.1998
- PhD student, Department of Radiotherapy, Netherlands Cancer Institute, Amsterdam, 1.0 fte.
Education
Certificates and/or registrations -
Dutch Society of Clinical Physics
Certificates and/or registrations -
Dutch Society of Clinical Physics
Doctorate -
Vrije Universiteit Amsterdam
04.1998
Master's degree -
University of Amsterdam
04.1994
Master's degree -
University of Amsterdam
04.1994
Skills
- Excellent programming skills in IDL and Matlab
- Moderate/good skills in python and R programming
Born
Amsterdam, 08/20/67
Civilclass
Married
Orciddbase
http://orcid.org/0000-0002-0313-5686
Researchinterests
Prof. Boellaard’s major research area is PET quantification, including the development and evaluation of PET instrumentation, image reconstruction and tracer kinetic modelling. In addition, he pursues the development and clinical evaluation of data-driven analysis of PET neuroreceptor imaging and on response measurement and criteria in oncology PET. Finally, he is presently coordinating several projects related to large axial field of view PET/CT.
Otherexperienceandprofessionalmemberships
- Member of the NeuroImaging Committee, European Association of Nuclear Medicine, Vienna, Austria
- Former member, vice chair and former chair of Physics Committee, European Association of Nuclear Medicine, Vienna, Austria
- Member of the scientific advisory board of the EANM Research Ltd. (EARL), 2010-present
- Member of Imaging workgroup, head of PET technology section, European Organisation of Research and Treatment of Cancer, Brussels, Belgium
- Member of the educational committee “Medical Imaging” of the Dutch Society of Clinical Physics, responsible for organising the educational program for clinical physicists Radiology and/or Nuclear Medicine
- Member of the Quantitative Imaging Biomarkers Alliance (QIBA) of the Radiological Society of Northern America (RSNA). Member of the PET/CT committee and member of the SUV and ROI subcommittees
- Co-organiser of the Dutch PET/CT physics course, endorsed by the Dutch Society of Clinical Physics (bi-annual course)
- Organiser of the Dutch PET Pharmacokinetic analysis course, endorsed by the Dutch Society of Clinical Physics (bi-annual course)
- Member of several (former and present) FP7 consortia (Euripides, DIMI, InMIND)
- Chair of WP3 (image analysis tools) of the CTMM Airforce consortium (till 2013)
- Vice chair of WP4 (data and image analysis) of the IMI Quic-Concept consortium
- Co-organiser of the Neuroreceptor meeting, Egmond, Netherlands, 2014
- Board member of the PET Center of Excellence of the Society of Nuclear Medicine (till 2013)
- Member of Scientific Committee MIRO 2010 & 2012 (joint ESTRO/EANM meeting)
- Member of Scientific Committee EANM annual conference 2011
- Participant of the organising committee of Brain 2005 conference (local organising committee)
Linguistics
native language, fluently, moderate understanding and speaking
Keywords
- PET quantification
- Kinetic modelling
- Image processing
- Delineation/segmentation
- PET image reconstruction
- Radiomics
- Artificial intelligence
Summaryofpublications
Several contributions to the Dutch Journal of Nuclear Medicine and to the Dutch Journal of Clinical Physics., Quick, H., Boellaard, R. Current image acquisition options in PET/MR. Chapter in Seminars in Nuclear Medicine, 2015., Van Berckel, B., Lammertsma, AA., Boellaard, R. Positron Emission Tomography. Chapter to be included in the OT of Neuroimaging, edited by Massimo Filippi, 2015., Boellaard, R. Medical Imaging: Principles and Practices. Editors Mostafa Analoui, Joseph D. Bronzino, Donald R. Peterson. CRC Press, 2012., Contributions to the chapters on quality control of PET and PET/CT systems in ‘Aanbelingen voor Nucleaire Geneeskunde”, 2009 & 2014., Boellaard R. Methodological aspects of multi-center studies with quantitative PET. Positron Emission Tomography Textbook. Editors: Juweid & Hoekstra, Humana press, 2010., Boellaard R. How do we get Cardiac Images from PET, CT and MRI: physical principles. Refresher corner, Heart & Metabolism, 2007., Lammertsma AA, Boellaard R, Hoekstra OS. Quantitative Issues in Response Measurement by PET. Response to Therapy Issue, ‘PET Clinics. Guest Editor. D.A. Mankoff., 2007., >100 invited lectures at national and international meetings and conferences., European guideline for standardisation of quantitative FDG PET, version 2, on behalf of the European Association of Nuclear Medicine, Eur.J.Nucl.Med.Mol.Imag., 2015., European guideline for standardisation of quantitative FDG PET, on behalf of the European Association of Nuclear Medicine, Eur.J.Nucl.Med.Mol.Imag., 2010., The Netherlands protocol for standardisation and quantification of FDG PET studies, officially approved in 2007 by the Netherlands Society of Nuclear Medicine, published in the Eur.J Nucl.Med.Mol.Imag., 2008., Contribution to the chapter on quality control of PET and PET/CT systems in ‘Aanbelingen voor Nucleaire Geneeskunde”, 2009 & 2015., Boellaard R, In vivo dosimetry with a liquid-filled electronic portal imaging device. Vrije Universiteit Amsterdam. Promotor: prof.dr G.M.M. Bartelink. Co-promotors: prof.dr. M van Herk and dr. BJ Mijnheer. 1998., V. Frings. In vivo quantification of proliferation and glucose metabolism in lung cancer patients. 2014., E. Verwer. Quantification and clinical application of novel oncology PET imaging biomarkers. 2015., N. Makris. Quantitative PET/CT imaging and dosimetry of 89Zr labelled compounds. 2015., M. Kropholler. Quantification of 11C-PK11195 PET brain studies. 2015., S. Golla. Kinetic analysis and quantification of PET neuroimaging studies. 2017., S. Mansor. Quantication and Kinetic Analysis of Brain PET Studies. 2017., I. Lopez Alves. Challenges and opportunities in quantitative brain PET imaging. 2017., C.A. Sánchez Catasùs. Brain perfusion SPECT analysis: New insights in mild cognitive impairment and neuromyelitis optica. 2018., M. Zhuang. Segmentation and quantitative analysis in whole-body PET imaging. 2019., G.M. Kramer. Validation of imaging biomarkers for response evaluation in lung and prostate cancer. 2019., A. Kaleep. Standardisation and harmonisation of quantitative oncology PET/CT studies. 2020., M. Cysouw. Quantitative Imaging of Small Tumours with Positron Emission Tomography. 2020., D. Peretti. Quantitative Brain PET Analysis Methods in Dementia Studies. 2020., E. Pfaehler. Methodological aspects and standardization of PET radiomics studies. 2021., G. Kolinger. Methods for improved PET quantification: Applications in Oncology and Neurology. 2021., T. Koopmans on multiparametric PET/MR analysis in head and neck cancer studies (methodological aspects). 2022., R. Martens on multiparametric PET/MR analysis in head and neck cancer studies (clinical aspects). 2022., C. Burggraaf. 18F-FDG PET as biomarker of aggressive lymphoma; technical and clinical validation. 2022., J. van Sluis. New PET technologies- Performance, image quality, and clinical implications. 2022., J. Eertink. New perspectives on the role of PET imaging in diffuse large B-cell lymphoma. 2023., R.Iqbal. Bridging the gap – from methodological developments towards clinical implementation of imaging biomarkers in lung and breast cancer.2023., P. Knaapen, Clinical Investigations of Myocardial Perfusion using Oxygen-15-labeled water and Positron Emission Tomography. 2007., M. Westerterp. Oesophageal cancer: novel diagnostic and therapeutic modalities. 2007., B. Rijbroek. Carotid surgery. Potential of cerebrovascular PET measurements. 2008., M. Yaqub. Quantification of brain PET studies. 2009., F. Van Velden. Optimal Reconstruction Algorithms for High-Resolution Positron Emission Tomography. 2009., J. Mourik. Image Derived Input Functions for Cerebral PET Studies. 2009., A. Schuitemaker. Inflammation in Alzheimer's disease- in vivo quantification. 2012., P. Cheebsumon. Quantification and Tumour Delineation in PET. 2012., U. Klumpers. Neuroreceptor imaging of mood disorder related systems. 2013., H. Folkersma. Activated microglia after traumatic brain injury: the neuroinflammatory mastermind. 2015., H. Saadani on quantitative FDG uptake metrics as prognostic and predictive biomarkers in melanoma patients., H. Tuncell on synaptic density PET imaging and neuroPET methodology., W. Luining on PSMA prostate imaging and radiomics analysis., M. Ferrandez-Ferrandez on use of AI for treatment response prediction with FDG PET/CT of DLBCL patients., A. Somasundaram on the use of radiomics in Zr-Mab studies., J. Wijngaarden on quantification of immunoPET studies., K. Vrakidis on novel total body PET/CT image reconstructions and cell tracking., C. Smith on clinical applicability and quantitative utility of total body PET/CT., M. Schaafsma on use of molecular imaging of patients with adrenal cancer., >500 peer reviewed publications in international journals, 91, 65
Personal Information
- Gender: Male
- Nationality: Dutch
Awards
- Grants, VIDI grant from the Netherlands Organisation for Scientific Research (600 kEuro). Project entitled “From hypothesis to data-driven analysis in neuroreceptor PET imaging” started in 2005.
- Grants, Center for Translation Molecular Medicine (CTMM), Airforce project, workpackage 3 (502kEuro), project started in 2008.
- Grants, Roche Postdoc Fellowship Program (200 kEuro), 2011-2012.
- Grants, Philips Research Exhibits (n=2, 4 years), Bursary for 2 Phd students, projects started in 2009.
- Grants, IMI Quic-Concept, deputy of work package 4 (250kEuro), awarded/started in 2011.
- Grants, Innovative Medical Devices Initiative grant (150 kEuro), awarded in 2013 by the Netherlands Organisation for Health Research and Development. Project 10-10400-98-006 entitled. “Quantitative multidimensional imaging for individualized treatment”.
- Grants, Investment Grant NWO Medium (1.2 MEuro), grant awarded in 2013. Project title “Establishing a multimodality preclinical imaging facility for fundamental research and efficient drug development”.
- Grants, Innovative Medical Devices Initiative grant (1.2MEuro), awarded in 2014. Project entitled “Multimodality and multi-parametric PET/MRI analysis for enhancing diagnosis, prognosis and response prediction in advanced stage head and neck cancer.”
- Grants, Multicentric Radiomics Compute Platform (P14-19 - project 1.1, 1.1MEuro), started in September 2016. Netherlands Organisation for Scientific Research (The Hague, Netherlands)
- Grants, Quantitative Imaging Biomarker Alliance (RSNA) NIBIB 6 project “SUV Qualification with Point Spread Function PET Reconstruction” (30kEuro) awarded in 2016
- Grants, European IMI project, Translational Imaging Methods in Drug Safety Assessment (TRISTAN), (250kEuro), awarded in 2016, started in Feb 2017
- Grants, Dutch Cancer Society (KWF 11648). Radiomics: extracting more tumour characteristics from PET/CT images for better prediction of outcome in DLBCL patients. (500kEuro), 01.2018-01.2022
- Grants, H2020 European Innovative Training Network (ITN) GRANT_NUMBER: 764458. HYBRID towards raising and supporting the next generation of creative and entrepreneurial cross-speciality imaging experts. (250kEuro for 1 ESR). 09.2017 – 09.2021.
- Grants, Neuroscience Amsterdam Alliance Project (BI-2019-03). PET image-based classification of amyloid and/or tau positivity in minimal cognitive impairment and Alzheimer’s disease (AD) and classification of abnormalities in dopamine transporter (DAT) SPECT in parkinsonian patients. (60kEuro), 2020-2021.
- Grants, H2020 European Innovative Medicine Initiative (IMI). IMMUNE-IMAGE: Specific imaging of immune cell dynamics using novel tracer strategies (WP2, 250kEuro), awarded and started in 2020.
- Grants, Hanarth Fonds, Artificial intelligence and machine learning for FDG PET/CT derived prognosis and response prediction in diffuse large B cell lymphoma (400kEuro), awarded in 2021, started in September 2021.
- Grants, Dutch Cancer Society (KWF 15560). Radiomics: extracting tumor characteristics from PET/CT images for better understanding of heterogeneity and prediction of outcome in Follicular lymphoma patients. (1000kEuro), 2024.
- Grants, Several smaller local grants (2020, 2021,2023,2024) provided by Cancer Centre Amsterdam or Neuroscience Amsterdam.
- Awards, Award for contributions to the PET center of excellence of the Society of Nuclear Medicine and Molecular Imaging, 2012, 2013.
- Awards, Esteemed investigator award (2013) for significant contributions to the development of the FDG PET/CT quantitative imaging biomarkers initiative (QIBA) profile by the Radiological Society of Northern America.
- Awards, Most cited paper award of the European Journal of Nuclear Medicine and Molecular Imaging, paper entitled “FDG PET and PET/CT: EANM procedure guidelines for tumour PET imaging: version 1.0”, 2014.
- Awards, American Association of Physicist in Medicine (AAPM) award. AAPM, 2017.
- Awards, Presidential recognition award for scientific contribution to the field of Nuclear Medicine. Society of Nuclear Medicine, 2022.
- Awards, Edward J. Hoffman memorial award for significant contribution to harmonisation and quantification of PET imaging and Nuclear Medicine. Society of Nuclear Medicine, 2023.
Hobbies and Interests
- Travelling
- Hiking
- Skiing
- Fitness/Spinning
- Cycling
Timeline
Full professor
Amsterdam University Medical Centers
01.2017 - Current
Full professor
University Medical Centre Groningen
01.2015 - 01.2017
Head of the Imaging Methodology section
VUmc
01.2012 - 01.2015
Full professor
VUmc
01.2011 - 01.2015
Coordinator of the PET physics group
VUmc
01.2004 - 01.2012
Clinical Physicist
VUmc
01.2001 - 01.2004
Training for clinical physicist
VUmc
01.1998 - 01.2001
PhD student
Netherlands Cancer Institute
01.1994 - 01.1998
Certificates and/or registrations -
Dutch Society of Clinical Physics
Certificates and/or registrations -
Dutch Society of Clinical Physics
Doctorate -
Vrije Universiteit Amsterdam
Master's degree -
University of Amsterdam
Master's degree -
University of Amsterdam
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