Innovative and driven Medicinal Chemist specializing in the design and synthesis of bioactive small molecules. Extensive expertise in MCRs, highthroughput methodologies, and scalable synthesis, with a strong focus on leveraging automated workflows to accelerate hit identification and lead optimization in modern drug discovery.
Hi, I’m
Mojgan Hadian
Medicinal Chemist
Schildwolde,GR
Summary
Overview
9
years of professional experience
3
Languages
Work History
University of Groningen
Ph.D. Researcher
12.2018 - 04.2023
Job overview
- Advanced Synthetic Organic Chemistry: Expert in designing and synthesizing novel compounds using synthetic organic chemistry techniques, including multicomponent reactions (MCRs), to advance drug discovery and medicinal chemistry
- High-throughput methodologies: Skilled in high-throughput synthesis and purification enabling efficient exploration of chemical space and optimization of lead compounds
- Automated Chemistry: Experienced in nanoscale automated chemistry using I-DOT positive pressure dispensers for high-throughput and automated nanoscale reactions
- Scalable Synthesis: Proficient in developing workflows for the synthesis of compounds from the milligram to gram scale, ensuring efficiency and high yield
- Purification: Utilized state-of-the-art chromatographic purification methods to ensure high purity of synthesized compounds such as Buchi
- Analytical Expertise: Proficient in utilizing advanced analytical techniques such as NMR, LC-MS, SFC, and HPLC for compound characterization, purity analysis, and structural identification
- SAR & Lead Optimization: Knowledgeable in designing and executing structure-activity relationship (SAR) studies and lead optimization to enhance compound potency, selectivity, and druglike properties
- Biological Evaluation Support: Designed and synthesized novel compounds to support biological evolution studies, contributing to drug discovery and target identification
- Parallel Synthesis & Purification: Conducted parallel synthesis and purification of compounds (singletons) for biological evaluation, optimizing efficiency in drug discovery
- Scientific Reporting & Communication: Drafted and documented comprehensive scientific reports and research findings, ensuring accurate data analysis and clear communication through peer-reviewed publications and presentations
University of Isfahan
M.Sc. in Organic Chemistry
09.2014 - 06.2017
Job overview
- Conducted a wide range of organic synthesis reactions to develop and synthesize novel small molecules and catalysts for various applications in medicinal chemistry and materials science
- Applied principles of nano chemistry and green chemistry to design and implement environmentally friendly, sustainable synthesis routes
- Characterized organic compounds using advanced analytical techniques, including NMR, IR, Mass Spectrometry, UV-Vis, and X-ray diffraction (XRD)
- Analysed inorganic compounds and nanoparticles with EDX, TGA, SEM, ICP
- Employed advanced purification methods including distillation, crystallization, and chromatography (flash, column, HPLC) to isolate and refine compounds to high purity
Education
University of GroningenGroningen, Netherlands
Ph.D. from Medicinal Chemistry
12.2018 - 4 2023
University Overview
- Thesis Statement: Innovative high throughput medicinal chemistry
- Design and synthesis of novel small molecules, alongside developing novel synthetic methodologies based on multicomponent reactions and innovative high throughput medicinal chemistry.
- Supervisor: Prof. Alexander Dömling
University of IsfahanIsfahan, Iran
M.Sc. from Organic Chemistry
09.2014 - 6 2017
University Overview
- Thesis: Synthesis and Characterization of 1-methyl Imidazolium Tetrachloroaluminate Immobilized on Functionalized Nanosilica and Investigation of its Catalytic Activity in the Synthesis of 2,3-Dihydroquinazolin-4(1H)ones
- Synthesized and characterized catalysts and applied them in synthesis novel small molecules.
- Supervisors: Prof. Iraj Mohammadpoor-Baltork
Islamic Azad University of Najafabad
B.Sc. from Chemistry
09.2010 - 6 2014
University Overview
Skills
Research and analysis
Conferences and symposia
Conferences and symposia
- MCR event at Chemelot/AMIBM, 2022, Presented PhD research to an interdisciplinary scientific audience.
- FIGON Dutch Medicines Days, 2022, Presented PhD research to an interdisciplinary scientific audience.
- HIPS Symposium, 2021, Presented PhD research to an interdisciplinary scientific audience.
- Pharmacy Day, University of Groningen, 2019-2022, Consistently presented PhD research to a multidisciplinary audience over four consecutive years, showcasing advancements in medicinal chemistry and engaging with peers.
Awards
Awards
Winner, Pharmacy Day, University of Groningen, 2022, Awarded for the best PhD research presentation.Publications
Publications
- Sustainability by design: automated nanoscale 2, 3, 4-trisubstituted quinazoline diversity, Hadian M, Shaabani S, Patil P, Shishkina SV, Böltz H, Dömling A, Green Chemistry, 2020, 22, 2459-67
- Marriage of high throughput synthesis and high throughput protein crystallography, Fandi Sutanto, Shabnam Shaabani, Rick Oerlemans, Eris Deniz, Pravin Patil, Mojgan Hadian, Meitian Wang, May Elizabet Sharpe, Matthew R. Groves, Alexander Dömling, Angewandte Chemie, 2021, 10.1002/anie.202105584
- Nanoporous Gold Catalyst for the Oxidative N-Dealkylation of Drug Molecules: A Method for Synthesis of N-Dealkylated Metabolites, Ali AlipourNajmi, Elchin Jafariyeh-Yazdi, Mojgan Hadian, Jos Hermans, Rainer Bischoff, Jun Yue, Alexander Dömling, Arne Wittstock, Hjalmar P. Permentier, ChemMedChem, 2022, 10.1002/cmdc.202200040
- Identification and Characterization of a small Molecule that Activates Thiosulfate Sulfurtransferase and Stimulates Mitochondrial Respiration, Zayana M. Al-Dahmani, Mojgan Hadian, Angel J. Ruiz-Moreno, Fernando A. Batista, Ran Zhang, Yang Luo, Afsaneh Sadremomtaz, Robin van der Straat, Mette Spoor, Amalia M. Dolga, Frank J. Dekker, Alexander S S Dömling, Harry van Goor, Matthew R. Groves, Protein Science, 2023, 10.1002/pro.4794
References
References
- Prof. Dr. Dr. (h.c.) Alexander Dömling, (ERA Chair)
Palacky University, CATRIN, Innovative Chemistry Group, Šlechtitelů 241/27
779 00, Olomouc – Holice, Czech Republic
phone +4915142065493
E-mail: alexander.domling@upol.cz
- Prof. Mattew Groves
Department of Drug Design
Groningen Research Institute of Pharmacy
Antonius Deusinglaan 1, 9713 AV Groningen, The Netherlands
Tel: +31 50 36 33305
E-mail: m.r.groves@rug.nl
Languages
Persian
Bilingual or Proficient (C2)
English
Bilingual or Proficient (C2)
Dutch
Intermediate (B1)
Availability
See my work availability
Not Available
Available
monday
tuesday
wednesday
thursday
friday
saturday
sunday
morning
afternoon
evening
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Websites
Timeline
Ph.D. Researcher
University of Groningen
12.2018 - 04.2023
University of Groningen
Ph.D. from Medicinal Chemistry
12.2018 - 4 2023
M.Sc. in Organic Chemistry
University of Isfahan
09.2014 - 06.2017
University of Isfahan
M.Sc. from Organic Chemistry
09.2014 - 6 2017
Islamic Azad University of Najafabad
B.Sc. from Chemistry
09.2010 - 6 2014
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