Summary
Overview
Work History
Education
Skills
Languages
Additional Information
Communication & Interpersonal Skills
Timeline
Generic
Kirti Krishnamurthy Iyer

Kirti Krishnamurthy Iyer

Nijmegen

Summary

Enthusiastic translational cancer research professional with 4+ years of experience in academia as a PhD candidate. Skilled at independently designing and executing various cell biology and molecular biology experiments on different preclinical models. Key player in successful collaborations across diverse research fields of cell biology, medical oncology, pharmacology and immuno-oncology. Clear communicator and flexible team player with problem solving and organizational skills. Adapts quickly and has worked on multiple projects in an innovative and dynamic environment.

Overview

4
4
years of professional experience

Work History

PhD Candidate

Radboud University Medical Center
12.2019 - 11.2023
  • Successfully established a patient derived metastatic colorectal cancer organoid living bio-bank.
  • Demonstrated the efficacy of an alternative intermittent dosing strategy of tyrosine kinase inhibitors (TKIs) in metastatic colorectal cancer (mCRC) organoids.
  • Optimized and established preclinical pharmacology experiments to determine the actual intra-cellular TKI concentrations.
  • Investigated the mechanism of action of cell death after the alternative intermittent TKI dosing treatment.


Education

Master of Science - Molecular Genetics & Biotechnology

Universiteit Leiden
Leiden, Netherlands
08.2019

Bachelor of Technology - Biotechnology

Vellore Institute of Technology
Vellore, Tamil Nadu, India
06.2017

Skills

  • Cell Culture and Cell Biology
  • Aseptic Cell culture techniques, Microbial cell biology, Isolation and culture of mammalian cell lines, zebrafish model, primary human 3D organoid cultures

  • Molecular Biology
  • Cloning, ligation, protein extraction, ELISA, DNA and RNA isolation, qRT-PCR, western blot, genetic manipulation of cell lines (siRNA, shRNA), plasmid isolation, viral propagation, immunohistochemistry, cell viability assays, Hemocytometer

  • Analytics
  • Flow cytometry, Liquid chromatography-tandem mass spectrometry (LC-MS/MS)

  • Data Analysis
  • Graphpad Prism, FlowJo, Data management on Electronic Lab Notebooks, Microsoft Office, Fusion 360, ImageJ

Languages

Tamil, Hindi
Native language
English
Proficient
C2
Dutch
Elementary
A2

Additional Information

  • Iyer, Kirti K., et al. “Lost in Translation: Revisiting the Use of Tyrosine Kinase Inhibitors in Colorectal Cancer.” Cancer Treatment Reviews, vol. 110, 1 Nov. 2022, p. 102466, www.sciencedirect.com/science/article/pii/S0305737222001359?via%3Dihub, 10.1016/j.ctrv.2022.102466. Accessed 8 Nov. 2022.


  • Iyer, K. K., Poel, D., Miggelenbrink, A., Kerkhof, W., Janssen, J., Bakkerus, L., ... & Verheul, H. M. (2023). High-dose short-term osimertinib treatment is effective in patient-derived metastatic colorectal cancer organoids. (10.1038/s44276-024-00042-0 / d15be620-1540-458c-a6d0-4718ac177e04 )


  • Subtil B, Iyer KK, Poel D, Bakkerus L, Gorris MAJ, Escalona JC, van den Dries K, Cambi A, Verheul HMW, de Vries IJM, Tauriello DVF. Dendritic cell phenotype and function in a 3D co-culture model of patient-derived metastatic colorectal cancer organoids. Front Immunol. 2023 Jan 25;14:1105244. doi: 10.3389/fimmu.2023.1105244. PMID: 36761758; PMCID: PMC9905679.




Communication & Interpersonal Skills

  • Excellent interdisciplinary team coordination learned through working with multiple teams consisting clinicians, pharmacologists, cell biologists and pathologists.
  • Possess outstanding written and verbal communication skills gained through various seminars and conferences during my graduate and post graduate studies.
  • Leadership skills gained by mentoring and guiding multiple masters and bachelor thesis students.
  • Good organization and time management skills gained as a volunteer of the Youth Red Cross society, responsible for managing blood donation camps and finding donors.
  • Strong analytical and critical thinking developed during the PhD tenure, interpreting data from both clinical and preclinical settings.

Timeline

PhD Candidate

Radboud University Medical Center
12.2019 - 11.2023

Master of Science - Molecular Genetics & Biotechnology

Universiteit Leiden

Bachelor of Technology - Biotechnology

Vellore Institute of Technology
Kirti Krishnamurthy Iyer